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Clemizole hydrochloride

CAS No. 1163-36-6

Clemizole hydrochloride ( AL 20; Allercur )

Catalog No. M10561 CAS No. 1163-36-6

An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Clemizole hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
  • Description
    An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells; also selectively and efficiently blocks TRPC5 currents and Ca(2+) entry with IC50 of 1-1.3 uM, 6-fold selectivity over TRPC4β (IC50 = 6.4 μM), and almost 10-fold selectivity over TRPC3 (IC50 =9.1 uM) and TRPC6 (IC50=11.3 uM), only very weakly affects TRPM3, TRPM8 and TRPV1, V2, V3, and V4 channels. HCV Infection Phase 2 Clinical
  • Synonyms
    AL 20; Allercur
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    NS4BH1histaminereceptor
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    1163-36-6
  • Formula Weight
    362.30
  • Molecular Formula
    C19H21Cl2N3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 3.6 mg/mL
  • SMILES
    Cl.ClC1=CC=C(CN2C(CN3CCCC3)=NC3=CC=CC=C23)C=C1
  • Chemical Name
    1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Richter JM, et al. Mol Pharmacol. 2014 Nov;86(5):514-21.
2. Einav S, et al. Nat Biotechnol. 2008 Sep;26(9):1019-27.
3. Einav S, et al. J Infect Dis. 2010 Jul 1;202(1):65-74.
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