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Clemizole hydrochloride
CAS No. 1163-36-6
Clemizole hydrochloride ( AL 20; Allercur )
Catalog No. M10561 CAS No. 1163-36-6
An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
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| 10MG | 58 | In Stock |
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| 25MG | 115 | In Stock |
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| 50MG | 222 | In Stock |
|
| 100MG | 354 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameClemizole hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAn H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
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DescriptionAn H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells; also selectively and efficiently blocks TRPC5 currents and Ca(2+) entry with IC50 of 1-1.3 uM, 6-fold selectivity over TRPC4β (IC50 = 6.4 μM), and almost 10-fold selectivity over TRPC3 (IC50 =9.1 uM) and TRPC6 (IC50=11.3 uM), only very weakly affects TRPM3, TRPM8 and TRPV1, V2, V3, and V4 channels. HCV Infection Phase 2 Clinical
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SynonymsAL 20; Allercur
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorNS4BH1histaminereceptor
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number1163-36-6
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Formula Weight362.30
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Molecular FormulaC19H21Cl2N3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 3.6 mg/mL
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SMILESCl.ClC1=CC=C(CN2C(CN3CCCC3)=NC3=CC=CC=C23)C=C1
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Chemical Name1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Richter JM, et al. Mol Pharmacol. 2014 Nov;86(5):514-21.
2. Einav S, et al. Nat Biotechnol. 2008 Sep;26(9):1019-27.
3. Einav S, et al. J Infect Dis. 2010 Jul 1;202(1):65-74.
2. Einav S, et al. Nat Biotechnol. 2008 Sep;26(9):1019-27.
3. Einav S, et al. J Infect Dis. 2010 Jul 1;202(1):65-74.
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